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Mostrando publicaciones 1-11 de 11
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HMGB1 decreases CCR-2 expression and migration of M2 macrophages under hypoxia
; ; ; ; ; ; Rojas, Armando
(2019)
Objective: The hypoxic milieu at tumor microenvironment is able to drive the behavior of infiltrating tumor cells. Considering that hypoxia-mediated HMGB1 release is known to promote tumor growth, as well to enhance the ...
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HMGB1 enhances the protumoral activities of M2 macrophages by a RAGE-dependent mechanism
Rojas, Armando; ; ; ; ; ; ; ; ; (2016)
The monocyte-macrophage lineage shows a high degree of diversity and plasticity. Once they infiltrate tissues,they may acquire two main functional phenotypes, being known as the classically activated type 1 macrophages ...
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Lysyl oxidase isoforms in gastric cancer
; ; ; ; ; ; Rojas, Armando; (2016)
Gastric cancer (GC) is the fifth most frequent cancer in the world and shows the highest incidence in Latin America and Asia. An increasing amount of evidence demonstrates that lysyl oxidase isoforms, a group of extracellular ...
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Pathogenic potential of Helicobacter pylori strains can explain differences in H. pylori associated diseases rates from Chile and Cuba
; ; Rojas, Armando; ; ; ; ; ; ; ; ; ; (2019)
Background: The prevalence of Helicobacter pylori-related diseases varies geographically and it is partially determined by the virulence of the circulating strains. Cuba and Chile exhibit different gastric cancer rates, ...
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Regional hereditary cancer program in Chile: a scalable model of genetic counseling and molecular diagnosis to improve clinical outcomes for patients with hereditary cancer across Latin America
(2024)Background Breast cancer is a leading cause of cancer-related mortality worldwide, with hereditary forms accounting for approximately 10% of cases. In Chile, significant gaps exist in genetic counseling and testing, ...
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RID: Evaluation of the possible inhibiting effect of the proinflammatory signaling induced by TNF-α through NF-κβ and AP-1 in two cell lines of breast cancer
; Rojas, Armando; ; ; ; ; ; ; (2020)
Receptor internalization and degradation (RID), is a transmembrane protein coded within the E3 region expression cassette of adenoviruses. RID downregulates the cell surface expression of epidermal growth factor receptor ...
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RID: evaluation of the possible inhibiting effect of the proinflammatory signaling induced by TNF-α through NF-κβ and AP-1 in two cell lines of breast cancer
; Rojas, Armando; ; ; ; ; ; ; (2020)
Receptor internalization and degradation (RID), is a transmembrane protein coded within the E3 region expression cassette of adenoviruses. RID downregulates the cell surface expression of epidermal growth factor receptor ...
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Skewed signaling through the receptor for advanced glycation end-products alters the proinflammatory profile of tumor-associated macrophages
Rojas, Armando; ; ; ; ; ; (2018)
Tumors are complex tissues composed of variable amounts of both non-cellular components (matrix proteins) and a multitude of stromal cell types, which are under an active cross-talk with tumor cells. Tumor-associated ...
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The emerging role of the receptor for advanced glycation end products on innate immunity
Rojas, Armando; ; ; ; ; (2014)
Cells from innate immune system are activated by the engagement of germ-line encoded patternrecognition receptors (PRRs) in response to the microbial insult. These receptors are able to recognize either the presence of ...
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The immunobiology of the receptor of advanced glycation end-products: Trends and challenges
; ; ; ; Rojas, Armando (2013)
Pattern-recognition receptors have been highly conserved in evolution. They recognize danger signals including both pathogen- and damage-associated molecular patterns, also known as alarmins. Several signaling pathways ...
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The receptor for advanced glycation end-products: A complex signaling scenario for a promiscuous receptor
Rojas, Armando; ; ; ; ; (2013)
Firstly described in 1992, the receptor for advanced glycation end-products has attracted increasing attention due to its diverse ligand repertoire and involvement in several pathophysiological processes associated with ...